Gadd45 Stress Sensor Genes

The Gadd45 family of proteins is a unique and critical stress sensor, involved in cell cycle arrest, DNA demethylation, repair, apoptosis, cell survival, genomic stability, and inflammation. This second edition is fully updated and provides a comprehensive overview of its global role.

Format: Hardback
Length: 153 pages
Publication date: 04 May 2022
Publisher: Springer Nature Switzerland AG

This second edition is a comprehensive update that delves into the emerging evidence highlighting the unique and critical role of the Gadd45 family of proteins as sensors of stress, encompassing genotoxic, physiological, and oncogenic stress. It sheds light on the intricate cellular stress response, encompassing a vast network of molecular pathways with an abundance of regulators and effectors.

The GADD45 stress response genes encode small (18 kDa) nuclear/cytoplasmic proteins that are rapidly induced by a diverse range of endogenous and exogenous stress stimuli. Despite their apparent similarities, Gadd45 genes exhibit distinct regulatory mechanisms and display functional diversity. These proteins respond to physiological and oncogenic stress, playing crucial roles in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation.

The primary objective of this book is to offer a comprehensive exploration of the extraordinary global role played by Gadd45 proteins as stress sensors and the intricate molecular pathways involved. By unraveling the complexities of the Gadd45 stress response, this edition aims to provide a valuable resource for researchers, scholars, and healthcare professionals seeking to understand the underlying mechanisms of stress response and its implications in various biological contexts.

Weight: 518g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030948030
Edition number: 2nd ed. 2022