Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

This book provides an overview of the progress in medical and scientific research toward converting chronic autoimmune diseases into drug-free reversible illnesses using hematopoietic stem cell transplantation (HSCT) and other cellular therapies. It covers various autoimmune diseases, including monogenetic, autoimmune aplastic anemia, neurologic, rheumatologic, dermatologic, and immune-mediated endocrinologic diseases. The text discusses the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. It also highlights the advantages of HSCT over conventional therapies and provides guidance on the entire process of stem cell therapy.

Format: Paperback / softback
Length: 666 pages
Publication date: 29 January 2024
Publisher: Taylor & Francis Ltd

This comprehensive book delves into the remarkable advancements in medical and scientific research aimed at transforming traditionally chronic autoimmune diseases into drug-free, reversible conditions through hematopoietic stem cell transplantation (HSCT) and other cellular therapies like T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells. By reintroducing sustained immune tolerance, these therapies hold immense potential for improving the lives of individuals affected by these debilitating conditions.

The book offers a wealth of information on various types of stem cells and immune cells, post-transplant immune regeneration, cellular regulatory requirements, ethical and economic considerations, and the advantages and disadvantages of HSCT in treating a diverse range of autoimmune diseases compared to current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders, including monogenetic autoimmune diseases, autoimmune aplastic anemia, neurologic immune diseases such as multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome, rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus, dermatologic diseases such as pemphigus, gastrointestinal disorders such as Crohns disease and celiac disease, and immune-mediated endocrinologic disease type I diabetes mellitus.

Detailed guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. This book serves as a valuable resource for healthcare professionals, researchers, and patients seeking to understand the latest developments in stem cell therapy for autoimmune diseases.

Weight: 1265g
Dimension: 280 x 210 (mm)
ISBN-13: 9781032065373