Heparins: Basic and Clinical Aspects

The Heparins: Properties and Clinical Applications provides comprehensive information on heparin, including its discovery, isolation, and characterization, and its use for the treatment of thrombotic disorders. It is a valuable resource for researchers and clinicians.

Format: Paperback / softback
Length: 214 pages
Publication date: 10 November 2020
Publisher: Elsevier Science Publishing Co Inc

The Heparins: Properties and Clinical Applications is a comprehensive resource that delves into the world of heparin, one of the most widely used drugs globally. This book offers a detailed account of the fascinating history of the discovery, isolation, and characterization of this biological agent, as well as its extensive use in the treatment of thrombotic disorders.

The author provides a comprehensive overview of the structures of various heparins, elucidating their function as anticoagulants. Through vivid illustrations and clear explanations, the book aims to provide researchers and clinicians with a concise and practical source of information that will aid in biomedical research, medical practice, and the pursuit of improved patient outcomes.

The discovery of heparin dates back to the early 1900s, when it was isolated from the mucous membranes of pigs. Initially, heparin was used as a blood thinner to prevent and treat thrombosis, a condition where blood clots form in blood vessels. Over the years, heparin has become an essential drug in the management of various medical conditions, including stroke, heart attack, and venous thrombosis.

One of the key properties of heparin is its ability to bind to and inactivate the clotting factors in blood. This anticoagulant effect is crucial in preventing the formation of blood clots, which can be life-threatening in certain situations. Heparin also has a low risk of bleeding, making it a safe and effective treatment option for many patients.

The different types of heparin are classified based on their chemical structure and molecular weight. There are over 80 different types of heparin, each with its unique properties and clinical applications. Some of the most commonly used heparins include unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and fondaparinux.

UFH is a natural derivative of heparin that is obtained from the liver of pigs. It has a relatively short half-life and requires frequent monitoring and adjustment of dosage to maintain an appropriate anticoagulant effect. LMWH, on the other hand, has a longer half-life and is less likely to cause bleeding complications. Fondaparinux, a synthetic derivative of heparin, has a more predictable anticoagulant effect and is less likely to interact with other medications.

In addition to its anticoagulant properties, heparin has several other clinical applications. It is used to prevent and treat postoperative complications, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). Heparin is also used to treat acute coronary syndrome (ACS) and unstable angina, where it helps to reduce the risk of blood clot formation and improve blood flow.

Despite its many benefits, heparin can also have side effects, including allergic reactions, bleeding, and thrombocytopenia. These side effects can occur in some patients, particularly those with underlying medical conditions or who are taking other medications that may interact with heparin. Therefore, it is essential to closely monitor patients who are receiving heparin and to adjust the dosage and frequency of administration as necessary to minimize the risk of side effects.

In conclusion, The Heparins: Properties and Clinical Applications is a valuable resource for researchers, clinicians, and healthcare professionals seeking to understand the world of heparin and its clinical applications. This comprehensive book provides a detailed account of the history, isolation, characterization, and use of heparin in the treatment of thrombotic disorders. It also offers a comprehensive overview of the structures of various heparins, their anticoagulant properties, and clinical applications. By providing a concise and practical source of information, this book aims to assist in biomedical research, medical practice, and the pursuit of improved patient outcomes.

Weight: 352g
Dimension: 217 x 138 x 11 (mm)
ISBN-13: 9780128187814