Hereditary Gastric and Breast Cancer Syndrome: CDH1: One Genotype with Multiple Phenotypes

The editors and authors of this book provide a comprehensive overview on hereditary breast and gastric tumors, including guidelines for clinical management, genetic screening, molecular mechanisms, pathological features, and surgical treatment. It covers epidemiological aspects, genetic pathways, pathological features, endoscopy, breast imaging, risk-reducing surgeries, and the experiences of two patients with hereditary cancer. The book is multidisciplinary and is essential reading for students, researchers, and specialists in the field.

Format: Hardback
Length: 422 pages
Publication date: 18 March 2023
Publisher: Springer International Publishing AG

This comprehensive book offers a thorough exploration of both basic research and clinical aspects related to hereditary breast and gastric tumors. In particular, its updated editorial content aims to provide valuable guidelines for the clinical management of patients afflicted with hereditary diffuse gastric and lobular breast cancer. A significant focus is placed on E-cadherin (CDH1 gene) germline mutations, genetic screening methodologies, the underlying molecular mechanisms, and the pathological and microscopic characteristics of these tumors. Additionally, the book endeavors to establish clinical criteria for genetic screening, while highlighting current surgical treatment options and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are also discussed in depth.

The book is organized into eight distinct sections, beginning with an epidemiological overview of gastric and breast cancers. This is followed by a section dedicated to presenting novel descriptions of genetic pathways implicated in hereditary cancer predispositions. The third section focuses on elucidating the pathological features of these diseases, with the aim of bridging the gap between cancer discovery and the development of effective cancer therapies. Subsequent sections of the book delve into endoscopy and breast imaging, as well as risk-reducing surgeries to mitigate the risk of cancer development. The sixth section serves as a platform for generating innovative ideas for identifying targets and developing novel treatment strategies. Finally, in the seventh section, the authors share the compelling stories of two patients and their experiences with the diagnosis and treatment of hereditary cancer.

This multidisciplinary book brings together experts from various scientific and technological fields, including medicine, surgery, and biology. The majority of the authors are affiliated with the International Gastric Cancer Linkage, emphasizing the collaborative nature of this endeavor. By pooling their expertise, the authors aim to advance our understanding of hereditary breast and gastric tumors and provide valuable insights into their clinical management. This book is a valuable resource for healthcare professionals, researchers, and individuals seeking to better understand and address the challenges posed by these genetic disorders.

Weight: 822g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031213168
Edition number: 1st ed. 2023