Hypoxia in Cancer: Significance and Impact on Cancer Therapy

This book explores the role of hypoxia in cancer initiation and progression, discussing its mechanisms in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores hypoxia imaging, its biological relevance, and mechanism of action. Additionally, it discusses the contribution of hypoxia to immune resistance and immune suppression/tolerance, the functional link between hypoxia and miRNA expressions, and the applications of tumor-on-a-chip technology for understanding the hypoxia-tumor microenvironment.

Format: Hardback
Length: 447 pages
Publication date: 15 April 2023
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the intricate role of hypoxia in cancer initiation and progression, shedding light on its mechanisms in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in diagnosing and treating cancer, providing an overview of hypoxia imaging, its biological relevance, and mechanism of action. Furthermore, it delves into the molecular mechanisms of hypoxia-induced senescence, its contribution to immune resistance and suppression/tolerance, and the identification of hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. The book also highlights the functional link between hypoxia and microRNA expressions and the role of hypoxia-regulated miRNAs in cancer cell survival in low oxygen environments. Additionally, it discusses the applications of tumor-on-a-chip technology in understanding the hypoxia-tumor microenvironment, making it a valuable resource for oncologists and scientists seeking to unravel the complexities of hypoxia in cancer.

Weight: 857g
Dimension: 235 x 155 (mm)
ISBN-13: 9789819903122
Edition number: 1st ed. 2023