Imaging Neuroinflammation

Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.

Format: Paperback / softback
Length: 512 pages
Publication date: 05 January 2023
Publisher: Elsevier Science & Technology

Imaging Neuroinflammation is a comprehensive guide that delves into the intricate molecular and cellular mechanisms underlying inflammation and its profound impact on neuroanatomy. It provides a thorough review of the state-of-the-art imaging tools available for measuring neuroinflammation, encompassing techniques such as MRI, neuroinflammation, MR Spectroscopy of inflammation, and Iron imaging in inflammation.

The book serves as an invaluable resource for researchers, clinicians, and students interested in understanding the role of neuroinflammation in various diseases. It offers a detailed exploration of the application of these imaging tools to both preclinical animal disease models and human disease, shedding light on the potential for precision medicine and personalized treatment strategies.

Chapter 1 provides an introduction to the concept of neuroinflammation, defining its origins, mechanisms, and potential consequences for brain health. It highlights the importance of studying neuroinflammation in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

Chapter 2 delves into the molecular mechanisms of neuroinflammation, exploring the role of immune cells, cytokines, and neurotransmitters in the activation and regulation of neuroinflammatory processes. It discusses the use of imaging techniques to detect and quantify these molecular markers of inflammation in the brain.

Chapter 3 explores the cellular basis of neuroinflammation, focusing on the activation and recruitment of immune cells to the brain, as well as the changes in neuronal morphology and function associated with inflammation. It discusses the use of imaging techniques to visualize these cellular processes and their relationship to disease progression.

Chapter 4 reviews the state-of-the-art imaging tools available for measuring neuroinflammation, including MRI, neuroinflammation, MR Spectroscopy of inflammation, and Iron imaging in inflammation. It provides an in-depth explanation of the principles and techniques behind each method, as well as their applications in studying neuroinflammation in different disease contexts.

Chapter 5 discusses the application of imaging tools to preclinical animal disease models and human disease. It highlights the importance of using animal models to study neuroinflammation and the benefits of combining imaging techniques with other experimental approaches. It also provides examples of how imaging has been used to diagnose and monitor neuroinflammatory diseases in humans.

Chapter 6 concludes the book by summarizing the key findings and highlighting the future directions for research in imaging neuroinflammation. It emphasizes the need for continued collaboration between researchers, clinicians, and industry to advance our understanding of neuroinflammation and develop new therapeutic strategies.

In conclusion, Imaging Neuroinflammation is a groundbreaking resource that provides a comprehensive overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy. It offers a detailed review of the state-of-the-art imaging tools available for measuring neuroinflammation and their applications to both preclinical animal disease models and human disease. By leveraging the power of imaging, researchers and clinicians can gain a deeper understanding of the underlying mechanisms of neuroinflammatory diseases and develop more effective treatment strategies. This book is a must-read for anyone interested in the field of neuroinflammation and brain health.

Weight: 450g
Dimension: 191 x 235 (mm)
ISBN-13: 9780323917711