Immune Strategies for Gastrointestinal Cancer

Immunotherapy has had great success in treating gastrointestinal cancers, and checkpoint inhibitors are the main class of drugs used. This book provides an overview of the evidence and discusses its future place in clinical practice. It is a valuable resource for oncologists, healthcare professionals, and biomedical scientists.

Format: Paperback / softback
Length: 296 pages
Publication date: 01 January 2024
Publisher: Springer International Publishing AG

Immunotherapy has emerged as a transformative treatment approach for various cancer types, and its significance in clinical practice is growing rapidly. The predominant class of immunotherapeutic drugs, known as checkpoint inhibitors, has revolutionized the immune system's ability to combat cancer by disengaging the physiological brakes that hinder its anti-cancer response. Malignancies of the gastrointestinal tract, which account for a significant portion of cancer cases worldwide, pose a significant burden of morbidity and mortality, underscoring the urgent need for more effective therapies. Numerous clinical trials have extensively evaluated the efficacy of cancer immunotherapy in gastrointestinal malignancies, revealing promising results in certain patient subsets.

This comprehensive book is designed to appeal to a diverse readership, including oncologists, healthcare professionals, and biomedical scientists. It provides a comprehensive overview of the available evidence surrounding immunotherapy in gastrointestinal cancers, exploring its potential applications and future implications in clinical practice. The book begins by discussing the background and mechanisms of immunotherapy, including its role in cancer immunosurveillance and the development of immune-mediated therapies. It then delves into the specific types of gastrointestinal cancers that have shown promising responses to immunotherapy, such as colorectal cancer, gastric cancer, and esophageal cancer.

The book extensively reviews the clinical trials that have been conducted to evaluate the efficacy of cancer immunotherapy in gastrointestinal malignancies. It highlights the key findings and outcomes of these trials, discussing the benefits and limitations of different treatment modalities and the potential for combination therapies. The authors also provide insights into the patient selection criteria, biomarker analysis, and monitoring strategies that are employed to optimize the outcomes of immunotherapy treatments.

In addition to its clinical applications, the book explores the future place of immunotherapy in gastrointestinal cancers. It discusses the ongoing research and development efforts aimed at improving the efficacy and safety of immunotherapeutic drugs, as well as the potential for personalized medicine approaches that tailor treatment to individual patient characteristics. The book also addresses the challenges and barriers that exist in the implementation of immunotherapy, including issues related to drug access, healthcare infrastructure, and patient education.

Overall, this book serves as a valuable resource for oncologists, healthcare professionals, and biomedical scientists seeking to stay updated on the latest developments in cancer immunotherapy. It provides a comprehensive and evidence-based overview of the available evidence surrounding immunotherapy in gastrointestinal cancers, exploring its potential applications and future implications in clinical practice. The book's multidisciplinary approach and expert insights make it an essential tool for those involved in the care and treatment of patients with gastrointestinal malignancies.

Weight: 574g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031399435
Edition number: 1st ed. 2023