Immuno-Oncology Crosstalk and Metabolism

This book explores the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment, promoting their growth and progression. It also highlights the deregulated metabolism in cancer cells and the involvement of immuno-onco metabolic cross-talk in resistance to chemo-radiation therapy.

Format: Hardback
Length: 218 pages
Publication date: 17 May 2022
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the intricate interplay between immune and tumor cells within the tumor microenvironment, shedding light on the mechanisms that drive their growth and progression. It also uncovers deregulated metabolism in cancer cells, which creates a suppressive and cancer-promoting microenvironment. Furthermore, the book offers novel insights into the metabolic alterations in immune cells that facilitate tumor cell growth and survival. In turn, it critically examines the role of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Additionally, the book explores the promising potential of immuno-oncology metabolism as a therapeutic strategy against cancer cells.

The immune system and tumor cells engage in a complex dialogue within the tumor microenvironment, leading to the promotion of tumor growth and progression. This intricate cross-talk involves various metabolic pathways, where immune cells and tumor cells exchange nutrients, metabolites, and signaling molecules to support their survival and growth. One of the key mechanisms is the activation of immune cells by tumor cells, which can lead to the production of inflammatory cytokines and the recruitment of other immune cells to the tumor site.

However, the immune system can also be hijacked by tumor cells to promote their growth and survival. Cancer cells can exploit deregulated metabolism to generate energy, synthesize proteins, and evade immune detection. This metabolic reprogramming allows cancer cells to evade immune surveillance, promote angiogenesis, and recruit immune cells that support their growth.

The involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) is another important aspect of this book. CRT is a standard treatment for many cancer types, but it can be ineffective due to the development of resistance by tumor cells. Immune-onco metabolic cross-talk plays a role in this resistance by altering the metabolism of immune cells, making them less effective in targeting and killing tumor cells.

To overcome these challenges, there is growing interest in the use of immuno-oncology metabolism as a therapeutic approach against tumor cells. Immuno-oncology metabolism refers to the study of the metabolic pathways and processes that regulate immune cell function and tumor cell growth. By understanding these pathways, researchers can develop new therapies that target the metabolic vulnerabilities of tumor cells, while sparing the healthy cells.

One promising approach is the use of metabolic inhibitors, which can block specific metabolic pathways that are essential for tumor cell growth. For example, drugs that target the mTOR pathway, which is involved in protein synthesis and cell growth, have shown promising results in treating certain types of cancer.

In addition, immuno-oncology metabolism can also be used to enhance the effectiveness of existing therapies. For example, combining chemotherapy with drugs that target immune-onco metabolic pathways can improve the response rate and survival rates of patients with cancer.

Another area of interest in immuno-onco metabolism is the development of personalized therapies that are tailored to the individual patient's tumor and immune profile. By analyzing the metabolic fingerprints of tumor cells and immune cells, researchers can identify specific targets for therapy and develop personalized treatment plans that are more effective and less toxic.

Despite the promising potential of immuno-onco metabolism as a therapeutic approach, there are still many challenges that need to be addressed. One of the biggest challenges is the lack of effective biomarkers that can predict the response to therapy and guide treatment decisions. Additionally, there is a need for more standardized and reproducible methods for studying immuno-onco metabolic pathways and processes.

In conclusion, this comprehensive book delves into the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment, shedding light on the mechanisms that drive their growth and progression. It also uncovers deregulated metabolism in cancer cells, which creates a suppressive and cancer-promoting microenvironment. Furthermore, the book offers novel insights into the metabolic alterations in immune cells that facilitate tumor cell growth and survival. In turn, it critically examines the role of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Additionally, the book explores the promising potential of immuno-oncology metabolism as a therapeutic strategy against cancer cells. By understanding the complex interplay between immune and tumor cells and the role of immuno-onco metabolic cross-talk, researchers can develop new and more effective therapies for cancer patients.

Weight: 512g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811662256
Edition number: 1st ed. 2022