In Vitro Drug Release Testing of Special Dosage Forms

This book provides guidance on the proper use of in vitro drug release methodologies to evaluate the performance of special dosage forms. It covers various techniques, including lipid-based oral formulations, chewable oral drug products, injectables, drug-eluting stents, inhalation products, transdermal formulations, topical formulations, vaginal and rectal delivery systems, and ophthalmics. The book is written by an international team of experts and includes contributions from well-respected global experts in dissolution testing. It will be a valuable resource for anyone working with special dosage forms, dissolution testing, drug formulation and delivery, pharmaceutics, and regulatory affairs.

\n Format: Hardback
\n Length: 312 pages
\n Publication date: 19 December 2019
\n Publisher: John Wiley & Sons Inc
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In the past decade, the use of drug release testing has expanded to include a wide range of novel and special dosage forms. To accurately predict the in vivo behavior of these dosage forms, it is crucial to consider various factors such as dosage form design, conditions at the site of application, and drug release site. This unique book is the first to comprehensively cover the field of in vitro release testing of special dosage forms in a single volume. Featuring contributions from an international team of experts, it provides an up-to-date overview of the state-of-the-art use of in vitro drug release methodologies for evaluating the performance of these unique formulations.

In Vitro Drug Release Testing of Special Dosage Forms encompasses the in vitro release testing of various types of dosage forms, including:

Lipid-based oral formulations: These formulations are designed to deliver drugs through the oral route and are often used for medications that have poor solubility in water.
Chewable oral drug products: These products are designed to be chewed and absorbed in the gastrointestinal tract, providing a convenient and easy-to-use alternative to traditional tablets or capsules.
Injectables: Injectables are medications that are administered through injection into the body. They can be used for a wide range of applications, including vaccines, antibiotics, and hormones.
Drug-eluting stents: Drug-eluting stents are medical devices used to treat coronary artery disease. They release drugs to prevent the growth of plaque and restenosis, which are the two main causes of heart attacks.
Inhalation products: Inhalation products are designed to deliver drugs directly into the lungs, where they can be absorbed into the bloodstream and provide rapid relief for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).
Transdermal formulations: Transdermal formulations are designed to deliver drugs through the skin, allowing them to bypass the gastrointestinal tract and enter the bloodstream directly. They are commonly used for medications that have poor oral bioavailability or for local treatment of conditions such as pain or inflammation.
Topical formulations: Topical formulations are designed to be applied directly to the skin or mucous membranes, providing localized treatment for conditions such as acne, eczema, and psoriasis.
Vaginal and rectal delivery systems: Vaginal and rectal delivery systems are designed to deliver drugs directly into the vagina or rectum, providing a convenient and discreet way to administer medications to women and men, respectively.
Ophthalmics: Ophthalmics are medications designed to treat eye conditions such as glaucoma, cataracts, and age-related macular degeneration. They are often administered in the form of eye drops or ointments.

The book concludes with a comprehensive look at regulatory aspects related to in vitro drug release testing. It discusses the current regulatory conditions for in vitro drug release testing and provides insights into the challenges and opportunities associated with this approach.

In summary, In Vitro Drug Release Testing of Special Dosage Forms is a valuable resource for anyone working with special dosage forms, dissolution testing, drug formulation, and delivery, pharmaceutics, and regulatory affairs. It provides a comprehensive overview of the state-of-the-art use of in vitro drug release methodologies and covers a wide range of dosage forms, including both oral and non-oral formulations. The book is written by well-respected global experts in the field, making it an essential reference for professionals in this industry.

\n Weight: 760g\n
Dimension: 175 x 249 x 21 (mm)\n
ISBN-13: 9781118341476\n \n