Integrated Structural Biology

This book provides an overview of contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems, including cryo-electron microscopy, computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy, dynamic nuclear polarization, electron paramagnetic resonance, (photo-)chemically induced dynamic nuclear polarization, X-ray crystallography, and small-angle X-ray and neutron scattering. It is targeted to both current practitioners and scientists interested in entering structural biology or biophysical chemistry.

Format: Hardback
Length: 386 pages
Publication date: 08 December 2023
Publisher: Royal Society of Chemistry

Modern research in biology increasingly relies on a diverse array of techniques to describe structures and mechanisms within complex biological systems. In response, this comprehensive book offers an insightful overview of contemporary integrated biology approaches employed for unraveling the intricate structures and understanding the functioning of these systems. Spanning several methodology chapters, the book delves into the latest advancements in cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy, dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography, and small-angle X-ray and neutron scattering (SAXS/SANS). These cutting-edge techniques are showcased in subsequent chapters, illustrating their synergistic application in addressing pressing problems at the forefront of structural biology. With a particular focus on scenarios where individual techniques fall short, the book provides valuable examples of biological systems encompassing membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes, and entire cells. Designed to cater to both established structural biologists and aspiring scientists interested in venturing into the fields of structural biology or biophysical chemistry, this invaluable resource provides a comprehensive foundation for advancing our understanding of biological structures and processes.

Weight: 759g
Dimension: 234 x 156 x 24 (mm)
ISBN-13: 9781839161834