Kinase Drug Discovery: Modern Approaches

Kinase inhibition is a promising area of research with many marketed drugs and compounds in clinical development. This book provides a forward-looking analysis of key areas, including screening approaches, modes of inhibition, novel approaches, molecular modelling, and immuno-oncology. It also highlights the importance of kinase mutations and pseudokinases as a target family.

\n Format: Hardback
\n Length: 413 pages
\n Publication date: 06 November 2018
\n Publisher: Royal Society of Chemistry
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Kinase inhibition continues to hold immense interest and increasing significance within academia and the pharmaceutical industry. A multitude of marketed drugs have been developed specifically to target kinases, and a substantial number of compounds are currently in various stages of clinical development. This second volume in the series takes a forward-looking approach to examining key areas of kinase inhibition in the forthcoming years. It builds upon the foundation established in the first volume, covering topics such as screening strategies for targeting kinases, diverse modes of inhibition, including allosteric and covalent mechanisms, novel approaches like macrocyclization, the evolution of kinase inhibitor properties, including their potential for brain penetration, recent advancements in molecular modeling techniques, and the significance of kinase mutations. Furthermore, the evolving biology of kinases has sparked increased interest in the immuno-oncology field and pseudokinases as a promising target family. As with the first volume, this book concludes with a forward-looking perspective on the potential advancements in research against this captivating target class.

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved,including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations. The evolving biology of kinases has also resulted in increased interest in the immuno-oncology area and also pseudokinases as a target family. As with the first volume the book finishes with a forward looking view of how research against this fascinating target class may evolve.

\n Weight: 790g\n
Dimension: 167 x 241 x 28 (mm)\n
ISBN-13: 9781788010832\n \n