Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents

The book "Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents" provides an overview of modern drug discovery and development approaches for treating Neglected Tropical Diseases (NTDs). It covers rational drug design approaches, validated targets, and serves as a guide for medicinal chemists and budding scientists.

Format: Paperback / softback
Length: 380 pages
Publication date: 31 March 2021
Publisher: Taylor & Francis Ltd

Here is the rephrased text:
Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents is a comprehensive resource that consolidates and elucidates contemporary drug discovery and development strategies employed to identify efficacious chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. The book is meticulously structured to cater to the requirements of medicinal chemists actively engaged in the development of chemotherapeutics for NTDs, as well as serve as a valuable guide for aspiring medicinal chemists interested in pursuing careers in this field. It will introduce rational drug design approaches employed in the creation of chemotherapeutics and provide an overview of validated targets that are available for the purpose.

Chapter 1 provides an introduction to NTDs, highlighting their global impact, economic burden, and the urgent need for effective treatments. It underscores the challenges faced in developing drugs for NTDs, including limited resources, complex disease biology, and the presence of drug-resistant strains. Chapter 2 explores the role of medicinal chemistry in NTD drug discovery, emphasizing the importance of structure-activity relationship (SAR) studies, computer-aided drug design (CADD), and high-throughput screening (HTS) in identifying potential leads.

Chapter 3 delves into the synthesis of antimicrobial agents for NTDs, covering various synthetic approaches, such as organic synthesis, semi-synthesis, and total synthesis. It discusses the challenges associated with the synthesis of complex molecules, including the optimization of reaction conditions, scalability, and the development of sustainable methodologies. Chapter 4 explores the pharmacokinetic and pharmacodynamic properties of antimicrobial agents, emphasizing the importance of understanding drug metabolism, distribution, and elimination in order to optimize drug therapy.

Chapter 5 discusses the evaluation of antimicrobial agents in preclinical studies, including in vitro and in vivo models. It highlights the importance of selecting appropriate animal models, designing robust study protocols, and interpreting data to assess the safety and efficacy of potential candidates. Chapter 6 explores the clinical development of antimicrobial agents for NTDs, including the design of clinical trials, regulatory considerations, and the challenges associated with drug approval.

Chapter 7 discusses the challenges of drug delivery for NTDs, including the development of suitable formulations, the optimization of drug administration routes, and the development of innovative delivery technologies. Chapter 8 explores the role of medicinal chemistry in the development of combination therapies for NTDs, emphasizing the importance of synergistic effects and the identification of novel drug combinations.

Chapter 9 discusses the challenges of drug resistance in NTDs, including the emergence and spread of drug-resistant strains, and the need for innovative approaches to combat resistance. Chapter 10 explores the role of medicinal chemistry in the development of vaccines for NTDs, emphasizing the importance of immunological mechanisms and the development of effective vaccine platforms.

Chapter 11 discusses the future of medicinal chemistry in NTD drug discovery, including emerging technologies, such as artificial intelligence (AI), machine learning (ML), and nanotechnology, and their potential applications in drug discovery and development.

In conclusion, Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents is a valuable resource for medicinal chemists, researchers, and healthcare professionals involved in the treatment of NTDs. It provides a comprehensive overview of contemporary drug discovery and development strategies, highlights the challenges faced in NTD drug discovery, and showcases the potential of medicinal chemistry in addressing these challenges. By providing a deep understanding of the medicinal chemistry of antimicrobial agents for NTDs, this book empowers researchers and practitioners to develop effective and sustainable treatments for these neglected diseases.

Weight: 706g
Dimension: 176 x 254 x 26 (mm)
ISBN-13: 9780367779252