Medicinal Chemist's Guide to Solving ADMET Challenges

The Medicinal Chemists Guide to Solving ADMET Challenges is a valuable resource for medicinal chemists and ADMET experts that provides practical design strategies and tactics to solve common ADMET issues in pharmaceutical and academic laboratories.

Format: Hardback
Length: 518 pages
Publication date: 27 August 2021
Publisher: Royal Society of Chemistry

The Medicinal Chemists Guide to Solving ADMET Challenges is a comprehensive resource that provides a wealth of design strategies and tactics for addressing common ADMET issues encountered in pharmaceutical and academic laboratories. This guide is designed to help readers quickly identify the most promising approaches applicable to their specific challenges, with a curated collection of concrete examples presented in a visually appealing "table-of-contents" style format. Each ADMET parameter is introduced in a concise yet comprehensive manner, including background information, relevance, and screening strategies.

The knowledge of how to modify molecular structure to solve ADMET issues in medicinal chemistry can be difficult to retrieve from literature, public databases, and even corporate data warehouses. This guide fills this gap by presenting state-of-the-art design strategies developed by a global group of experienced medicinal chemists and ADMET experts from academia and the pharmaceutical industry.

The guide begins by providing an overview of ADMET challenges and their significance in drug development. It then delves into the various design strategies and tactics employed to overcome these challenges, including structure-activity relationship (SAR) analysis, molecular modeling, and in silico screening. Each strategy is explained in detail, with examples and case studies to illustrate their application.

Furthermore, the guide discusses the importance of considering ADMET parameters early in the drug discovery process and how they can impact the success of a drug candidate. It provides guidance on how to optimize ADMET properties, such as solubility, permeability, and metabolism, to improve the drug's safety and efficacy.

The Medicinal Chemists Guide to Solving ADMET Challenges is an invaluable resource for medicinal chemists, drug discovery researchers, and anyone involved in the development of new drugs. It offers a comprehensive and practical approach to addressing ADMET challenges, providing readers with the knowledge and tools they need to succeed in their endeavors.

Weight: 964g
Dimension: 164 x 240 x 37 (mm)
ISBN-13: 9781788012270