Modeling the 3D Conformation of Genomes

This book provides a comprehensive summary of physical modeling approaches applied to biological datasets, covering various aspects of chromosome conformation and biophysical mechanisms. It covers introductory chapters to advanced modeling techniques and applications, making it a valuable resource for researchers in the field.

Format: Paperback / softback
Length: 370 pages
Publication date: 31 March 2021
Publisher: Taylor & Francis Ltd

This comprehensive book offers a timely and insightful overview of physical modeling techniques applied to biological datasets, providing a detailed account of the conformational properties of chromosomes within the cell nucleus. The book is organized into chapters that guide readers through the process of converting raw experimental data into three-dimensional conformations, while also highlighting the importance of models in understanding the biophysical mechanisms that govern chromosome conformation. Spanning from introductory chapters to advanced topics related to polymer physics, data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure, this book offers a comprehensive coverage of the field.

By leveraging the power of physical modeling, researchers can gain a deeper understanding of the intricate relationships between chromosome structure, function, and disease. The book provides valuable insights into the development of new therapeutic strategies and diagnostic tools for genetic disorders, as well as advancing our knowledge of genome organization and evolution.

With its extensive content, authoritative reviews, and practical applications, this book is an essential resource for researchers, students, and practitioners in the fields of biophysics, genetics, and genomics. It will undoubtedly inspire future research and advancements in this rapidly evolving field.

Weight: 717g
Dimension: 234 x 156 (mm)
ISBN-13: 9780367780456