Molecular Hematopathology: An Integrated Case-Based Approach

Molecular Hematopathology: An Integrated Case-Based Approach is a book that provides readers with an integrated case-informed learning experience of Molecular Hematopathology, focusing on best-practice neoplastic hematopoietic disorders and related conditions. It reviews diagnostic approaches using morphologic analysis, flow cytometry, and genetic testing and includes summary tables and quiz questions for self-study. The book demonstrates how novel advances in molecular and cellular biology translate to modern pathology practice.

Format: Hardback
Length: 326 pages
Publication date: 30 June 2022
Publisher: American Society of Clinical Pathologists Press

Molecular Hematopathology: An Integrated Case-Based Approach is a comprehensive textbook that offers readers an immersive and case-informed learning experience in the field of Molecular Hematopathology. Focusing on best-practice neoplastic hematopoietic disorders and related conditions, this book provides a thorough exploration of diagnostic approaches that leverage a combination of morphologic analysis, flow cytometry, and genetic testing (cytogenetics, FISH, PCR, and/or NGS). By reviewing these diagnostic methodologies, readers will gain a profound understanding of Molecular Hematopathology and its applications.

Rather than being a mere catalog of every hematologic neoplasm with a defined cytogenetic or molecular abnormality, this text delves into the study of cases that illustrate how specific chromosomal and molecular findings are utilized for diagnosis, prognosis, and the consideration of targeted therapy. Each individual chapter includes summary tables that compare the described malignancy with similar entities, thus encompassing a wide range of specific hematologic disorders throughout the text. Additionally, two sets of quiz questions are provided to aid in self-study.

The Appendices offer a concise overview of cytogenetic and molecular techniques, including a comprehensive guide to reading next-generation sequencing (NGS) data. Standard nomenclature (compliant with the 2017 WHO Classification) is used throughout the book to ensure clarity and consistency.

Hematopathology has undergone several revolutionary periods, including the development of a classification system that defines distinct and real entities (later evolved to the current WHO classification of hematologic neoplasms), advancements in sophisticated immunophenotyping techniques such as flow cytometry, and most recently, an explosion in molecular/genetic testing that has significantly expanded our understanding of the pathophysiology of hematologic disease.

The extent, applications, and ramifications of the genomic revolution in hematopathology are vast and far-reaching. This field has the potential to revolutionize the way we diagnose, treat, and manage hematologic disorders, leading to improved patient outcomes and a better understanding of the underlying mechanisms of these diseases. Molecular Hematopathology: An Integrated Case-Based Approach serves as a valuable resource for medical professionals, researchers, and students seeking to stay up-to-date with the latest advancements in this field. By providing a comprehensive and case-informed approach, this book equips readers with the knowledge and skills necessary to excel in Molecular Hematopathology and contribute to the ongoing progress in this rapidly evolving area of medicine.

ISBN-13: 9780891896814