Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies

Multi-drug resistance (MDR) in cancer is a major barrier to successful chemotherapy, causing 90% of cancer patient deaths. This book discusses the mechanisms underlying MDR and the targets of novel chemotherapeutic agents to guide future research concerning new effective strategies in cancer treatment. It is written for pharmaceutical and biomedical scientists and researchers interested in the mechanisms and strategies for overcoming cancers multi-drug resistance.

Format: Hardback
Length: 224 pages
Publication date: 02 August 2023
Publisher: John Wiley & Sons Inc

Cancer remains a formidable global adversary, despite significant advancements in treatment. Chemotherapy remains a cornerstone of modern cancer care, despite the challenges posed by the progression of cellular resistance to numerous independent anticancer drugs. Multi-drug resistance (MDR) is a prevailing phenomenon observed in most cancer patients, significantly contributing to the high mortality rate associated with cancer. According to alarming statistics, drug resistance accounts for 90% of cancer patient deaths. Prolonged chemotherapy often leads to refractory cancer and tumor recurrence, highlighting the urgent need for effective treatment strategies. The prevalence of drug-resistance mutations further exacerbates the challenge of tumor treatment, diminishing the therapeutic efficacy of drugs.

In response to this pressing need, Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies emerges as a comprehensive resource. Comprising nine chapters, this book delves into various aspects of MDR, encompassing the study of autophagy-mediated drug resistance, the role of efflux transporters, the expression of drug transporters, resistance to targeted therapies in breast cancer, advancements in metallodrug-driven combination treatment for cancer, and the utilization of natural agents to overcome cancer drug resistance.

The primary objective of this book is to provide the most up-to-date data on the mechanisms of cellular resistance to anticancer agents currently employed in clinical treatment. By offering a deeper understanding of MDR and the targets of novel chemotherapy agents, it aims to guide future research toward developing innovative and effective strategies for cancer treatment.

The intended audience for this book includes pharmaceutical and biomedical scientists, researchers, and healthcare professionals engaged in the field of cancer research and treatment. It serves as a valuable resource for those seeking to stay abreast of the latest developments and advancements in the battle against cancer.

With its comprehensive coverage, insightful analysis, and practical insights, Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies is poised to make a significant impact on the field of cancer research and treatment. By unraveling the complexities of MDR and exploring novel treatment approaches, this book contributes to the ongoing efforts to improve cancer outcomes and enhance the quality of life for patients suffering from this devastating disease.

ISBN-13: 9781394209217