Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery

This second edition of a book on natural product biosynthesis covers the types of natural products, biosynthetic pathways, and the discovery of novel products in the post-genomic era. It integrates new findings into the principles of the first edition and highlights the role of pericyclases in biosynthetic complexity generation. The text is a valuable resource for chemists, bioinformaticians, computational biologists, pharmacognocists, chemical ecologists, bioengineers, and synthetic biologists.

Format: Hardback
Length: 794 pages
Publication date: 14 December 2022
Publisher: Royal Society of Chemistry

This extensively revised and updated edition, written by renowned experts in the field of natural product biosynthesis, offers a comprehensive description of the diverse types of natural products, the biosynthetic pathways that facilitate their production, and a comprehensive update on the discovery of novel products in the post-genomic era. Despite the isolation and characterization of approximately 500,000 to 600,000 natural products over the past two centuries, it is estimated that there exists a tenfold greater inventory of these compounds that remains to be explored, primarily based on predictions of biosynthetic gene clusters. The approach of this book is to elucidate the chemical logic underlying the assembly of natural product structural classes, starting from the building blocks of primary metabolism.

In this second edition, numerous groundbreaking findings have been seamlessly integrated into the principles established in the first edition. These principles categorized natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery responsible for constructing the diverse and intricate end product metabolites. New chapters have been added to cover the evaluation of a core set of thermodynamically activated but kinetically stable metabolites that drive both primary and secondary metabolic pathways. Additionally, over the past decade, significant progress has been made in validating the existence of various pericyclase classes, which play a crucial role in generating biosynthetic complexity in almost every major category of natural products.

This text serves as a valuable resource for chemists across various subdisciplines, including synthetic organic chemists and medicinal chemists. It is also of immense value to bioinformatic and computational biologists, as well as pharmacologists. By providing a comprehensive and up-to-date understanding of natural product biosynthesis, this text will undoubtedly contribute to advancing our knowledge in this field and facilitating the development of new therapeutic agents and materials.

Weight: 1782g
Dimension: 253 x 196 x 53 (mm)
ISBN-13: 9781839165641
Edition number: 2 New edition