Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery

This book provides comprehensive information about Actinomycetes, covering their ecology, diversity, and applications in drug discovery. It discusses the discovery of natural products from Actinomycetes, chemical biology, and genomic and synthetic biology approaches. It highlights the use of advanced tools and technologies to accelerate the discovery and development of new natural products with medicinal and industrial applications.

Format: Paperback / softback
Length: 508 pages
Publication date: 17 April 2023
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the intricate world of Actinomycetes, covering their ecology, diversity, and applications in great detail. It is organized into two main sections. The first part explores the diverse nature, chemical biology, and ecology of these microorganisms, shedding light on their discovery of natural products from soil, endophytic, and marine sources. It also discusses innovative methods for identifying secondary metabolites, elucidating their structures, and conducting biosynthetic research. The chapters in this section delve into the molecular mechanisms underlying biological and chemical elicitation of secondary metabolism in Actinomycetes.

The second part of the book focuses on genomic and synthetic biology approaches in Actinomycetes drug discovery. It includes chapters that discuss the application of metabolic engineering to enhance natural product synthesis and the utilization of omics data in engineering regulatory genes. This section also highlights advanced tools such as cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for the overproduction of natural products in Actinomycetes. It describes the use of bioinformatics tools for reprogramming biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering.

The authors of this book anticipate that the advanced genomic and molecular tools discussed herein will expedite the discovery and development of new natural products from Actinomycetes, with potential applications in medicine and various industrial sectors. This book is a valuable resource for researchers and students in the fields of microbiology, pharmaceutical sciences, and drug discovery.

Weight: 795g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811661341
Edition number: 1st ed. 2022