Near-infrared Speckle Contrast Diffuse Correlation Tomography for Noncontact Imaging of Tissue Blood Flow Distribution

Near-infrared speckle contrast diffuse correlation tomography (scDCT) is a novel imaging technique that provides full 3D blood flow distributions in tissues. It offers advanced features such as high sampling density, fast data acquisition, noninvasiveness, noncontact, affordability, portability, and translatability across varied subject sizes. Its extensive applications include imaging of cerebral blood flow in mice, rats, and piglets, as well as clinical human testing results on preterm infants and sensitive burn tissues. Supporting activities include integrated capability for acquiring surface curvature information, rapid 2D blood flow mapping, and optimizations via tissue-like phantoms and computer simulations.

Format: Hardback
Length: 56 pages
Publication date: 07 November 2022
Publisher: Taylor & Francis Ltd

Imaging of tissue blood flow (BF) distributions holds immense significance in the diagnosis and therapeutic monitoring of diverse vascular diseases. The groundbreaking near-infrared speckle contrast diffuse correlation tomography (scDCT) technique emerges as a revolutionary approach, delivering comprehensive 3D BF distributions. In comparison to competing technologies, scDCT offers a multitude of advanced features, including high sampling density, rapid data acquisition, noninvasiveness, noncontact, affordability, portability, and translatability across varying subject sizes.

The fundamental principles, instrumentation, and data analysis algorithms are meticulously outlined, providing a comprehensive understanding of the technique. Extensive applications are summarized, encompassing imaging of cerebral BF (CBF) in mice, rats, and piglet animals with skull penetration into deep brain regions. Clinical human testing results are described, showcasing the recovery of BF distributions on preterm infants through incubator wall penetration and on sensitive burn tissues and mastectomy skin flaps without direct device-tissue interactions. Supporting activities, such as integrated capability for acquiring surface curvature information, rapid 2D blood flow mapping, and optimizations through tissue-like phantoms and computer simulations, are outlined to further enhance the understanding and utilization of scDCT.

These applications and activities serve as valuable guides for researchers and practitioners, highlighting the expected capabilities and limitations of scDCT in preclinical/clinical research, constrained environments (e.g., neonatal intensive care unit bedside), and vulnerable subjects and measurement sites. By delving into these details, readers can gain insights into the potential of scDCT to revolutionize the field of vascular imaging and advance healthcare outcomes.

Weight: 281g
Dimension: 216 x 138 (mm)
ISBN-13: 9781032133874