Neurochemical Systems and Signaling: From Molecules to Networks

The human brain is made up of billions of neurons that communicate with each other through chemical messengers, which can cause diseases. There are more than 20 neurotransmitter systems and multiple receptors for each neurotransmitter, and any alterations in neurochemical balance are expressed in the form of neurological or psychiatric disorders. This book provides a comprehensive overview of the neurological diseases associated with neurochemical imbalances, including neurotransmission, neuronal signaling, and related neurological disorders.

Format: Hardback
Length: 310 pages
Publication date: 31 March 2023
Publisher: Taylor & Francis Ltd

The human brain is a remarkable organ composed of billions of neurons that intricately interact with one another through the use of chemical messengers, known as neuroactive substances. These neuroactive substances encompass a wide range of compounds, including neurotransmitters, neuromodulators, and neurohormones. It is worth noting that certain neurotransmitters also possess dual roles as neuromodulators and neurohormones. However, achieving a universal consensus on the precise meanings of these neuroactive substances, including neurotransmitters, neuromodulators, and neurohormones, remains a challenging task due to the historical loose usage of the term "neurotransmitter." This term has traditionally encompassed a wide range of compounds, including neurotransmitters, neurohormones, and neuromodulators.

Any disruptions in the functioning of these neuroactive substances can lead to a wide array of diseases, affecting both the neurological and psychiatric realms. The central nervous system, as the ultimate hub of neuronal communication, is a complex network of systems with numerous neurotransmitter systems. In contrast, the autonomic nervous system primarily operates on two distinct pathways: the parasympathetic system, responsible for the "rest and digest" phenomenon, and the sympathetic system, associated with the "fight or flight" response. The central nervous system boasts over 20 distinct neurotransmitter systems, each with its own unique set of receptors.

It is important to recognize that any alterations in neurochemical balance are reflected in the form of neurological and psychiatric disorders. Epilepsy, Parkinson's disease, Alzheimer's disease, psychosis, depression, and many other conditions are manifestations of disturbed neurochemical equilibrium. Among the various neurotransmitters, acetylcholine, noradrenaline, dopamine, and serotonin (5-HT) hold significant importance due to their profound roles in the pathogenesis of various neurological and psychiatric disorders.

Understanding the intricate interplay between these neuroactive substances and their effects on brain function is crucial for developing effective treatments and interventions for neurological and psychiatric disorders. Ongoing research and advancements in neuroscience are shedding light on the mechanisms underlying these disorders, providing new avenues for therapeutic interventions and improving the quality of life for individuals affected by these conditions.

Dimension: 280 x 210 (mm)
ISBN-13: 9780367210625