Neuronal Cell Death: Methods and Protocols

This volume provides comprehensive methods to assess structural and ultrastructural changes in mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques. It covers topics such as neurodegeneration, in vivo modeling, single cell clonal analysis, and genome and proteomic methods. Written in the Methods in Molecular Biology series format, the book is a valuable resource for scientists and researchers interested in learning more about neuronal cell death.

Format: Hardback
Length: 357 pages
Publication date: 02 July 2022
Publisher: Springer-Verlag New York Inc.

This comprehensive volume delves into advanced methodologies for assessing structural and ultrastructural alterations in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques, including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book encompass a wide range of topics, such as the analysis of neurodegeneration in post-mortem characterization of preclinical animal models, in vivo modeling of cell death in various model systems and brain organoids, single-cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analyzing mRNA dynamics and quantifying targeted peptides. Written in the renowned Methods in Molecular Biology series format, the chapters feature introductions to their respective subjects, comprehensive lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and helpful tips on troubleshooting and avoiding known pitfalls.

Neuronal Cell Death: Methods and Protocols is an invaluable resource for scientists and researchers seeking to delve deeper into this rapidly evolving field.

Weight: 896g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071624081
Edition number: 1st ed. 2022