Non-Neoplastic Diseases of the Liver

This fascicle provides a practical reference for pathologists in diagnosing liver biopsies, focusing on diagnostic histopathology, differential diagnosis, and integrating clinical features, laboratory findings, and pathophysiology. Special stains and immunohistochemistry are also discussed.

Format: Hardback
Length: 514 pages
Publication date: 28 February 2022
Publisher: American Registry of Pathology

This fascicle serves as a comprehensive and invaluable resource for pathologists who delve into the intricate realm of liver biopsy analysis, a demanding and critical component of diagnostic surgical pathology. With a primary focus on diagnostic histopathology, it delves into the intricate patterns of diseases, emphasizing differential diagnosis. The book seamlessly weaves together key aspects of clinical features, laboratory findings, and pathophysiology, providing a holistic understanding of liver disorders. Moreover, it incorporates the application and interpretation of special stains and immunohistochemistry into its discussions, enhancing the diagnostic accuracy and precision of liver biopsy interpretations. By offering a wealth of information and expert guidance, this fascicle empowers pathologists to confidently navigate the complexities of liver pathology and deliver accurate diagnoses to patients.

Introduction:
The liver is a vital organ responsible for numerous essential metabolic and digestive processes, making it a crucial component of overall health. However, the diagnosis of liver disorders can be challenging due to the complexity of its structure and function. Liver biopsies are a crucial tool in the evaluation of liver diseases, allowing pathologists to examine tissue samples in detail and make accurate diagnoses.
Primary Goal:
The primary goal of this fascicle is to serve as a practical reference for pathologists who review liver biopsies. It aims to provide comprehensive and up-to-date information on diagnostic histopathology, focusing on the patterns of diseases and their differential diagnosis. The book will discuss various clinical features, laboratory findings, and pathophysiological mechanisms associated with liver disorders, enabling pathologists to interpret these data effectively.
Emphasis on Differential Diagnosis:
Differential diagnosis is a critical aspect of liver pathology, as it involves distinguishing between various liver diseases that may present with similar clinical symptoms and laboratory findings. This fascicle will provide detailed discussions on the diagnostic criteria and features of various liver diseases, including viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, liver tumors, and other conditions. The authors will illustrate these disease patterns with numerous high-quality images and illustrations, aiding pathologists in recognizing and differentiating between different disease entities.
Clinical Features:
Clinical features play a crucial role in the diagnosis of liver disorders. The authors will discuss the common presenting symptoms, physical examination findings, and laboratory tests that are used to evaluate liver function and assess the presence of liver disease. They will also highlight the significance of imaging modalities, such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), in the diagnostic process.
Laboratory Findings:
Laboratory findings are essential in the diagnosis of liver disorders. The authors will provide detailed descriptions of the various laboratory tests that are used to evaluate liver function, assess liver injury, and detect the presence of liver diseases. They will discuss the normal ranges and abnormal values for these tests, as well as the significance of abnormal findings in the diagnostic process.
Pathophysiology:
Understanding the pathophysiology of liver disorders is crucial for accurate diagnosis and treatment planning. The authors will discuss the underlying mechanisms of liver diseases, including viral infections, alcohol-related injury, non-alcoholic fatty liver disease, and liver tumors. They will provide insights into the cellular and molecular processes that contribute to the development and progression of these diseases, enabling pathologists to develop a comprehensive understanding of the pathogenesis of liver disorders.
Special Stains and Immunohistochemistry:
Special stains and immunohistochemistry are powerful tools in the diagnosis of liver disorders. The authors will discuss the application and interpretation of these techniques, highlighting their role in differentiating between various liver diseases and detecting specific markers of disease activity. They will provide detailed descriptions of the techniques used, as well as the interpretation of the results obtained.
Conclusion:
In conclusion, this fascicle serves as a valuable resource for pathologists who review liver biopsies. It provides comprehensive and up-to-date information on diagnostic histopathology, focusing on the patterns of diseases and their differential diagnosis. By integrating clinical features, laboratory findings, pathophysiology, special stains, and immunohistochemistry, the book empowers pathologists to confidently navigate the complexities of liver pathology and deliver accurate diagnoses to patients.

Weight: 1814g
Dimension: 279 x 220 (mm)
ISBN-13: 9781933477183