Optical Whispering Gallery Modes for Biosensing: From Physical Principles to Applications

This book provides an interdisciplinary overview of optical whispering gallery mode (WGM) microcavities, light-matter interaction, and biomolecular structure with a focus on applications in biosensing. It covers the fundamentals of WGM microcavities, LSPRs in metal nanoparticles, and biosensors based on their hybridization. It also discusses advanced in vivo biosensing techniques using WGM microcavities, including photothermal sensing, trapping neutral atoms, and optoplasmonic sensing. The second edition includes a new chapter on advanced in vivo biosensing techniques and chapter-end problems to inspire further research in this field.

Format: Hardback
Length: 481 pages
Publication date: 02 September 2022
Publisher: Springer International Publishing AG

This comprehensive and interdisciplinary book delves into the fundamentals of optical whispering gallery mode (WGM) microcavities, light-matter interaction, and biomolecular structure, with a particular emphasis on their applications in biosensing. By combining the unique properties of WGM microcavities with localized surface plasmon resonances (LSPRs) in metal nanoparticles, novel biosensors have emerged as the most sensitive microsystem biodetection technology, capable of single molecule detection without the need for amplification or labeling of the analyte.

The book offers an extensive survey of the physical mechanisms underlying WGM and LSPR-based biosensing, covering affinity, concentration, size, shape, and orientation of biomarkers. It also provides insights into different classes of biomolecules, their optical properties, and their significance in label-free clinical diagnostics.

In this expanded and updated second edition, a new chapter introduces advanced in vivo biosensing techniques using WGM microcavities. It explores photothermal sensing, methods for trapping neutral atoms around WGM microcavities, and practical aspects of optoplasmonic sensing. Additionally, the second edition now provides a comprehensive introduction to the use of WGM microcavities in physical sensing, encompassing measurements with frequency combs, macro and micro (one atom) lasers, gyroscopes, optomechanical and parity-time-symmetric sensor devices.

Chapter-end problems further enrich this textbook, encouraging aspiring physicists, bioengineers, and medical professionals to make their own groundbreaking contributions in this rapidly evolving field. This textbook serves as a valuable resource for both introductory and advanced courses on the modern optics of optical microcavities.

Weight: 1001g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031068577
Edition number: 2nd ed. 2022