Peptide and Peptidomimetic Therapeutics: From Bench to Bedside

Peptide and Peptidomimetic Therapeutics: From Bench to Beside provides applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. It covers fundamental peptide science, protein-protein interactions, peptide synthesis, and peptide drug delivery, targeting specific disease types, including infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders.

Format: Paperback / softback
Length: 416 pages
Publication date: 01 August 2022
Publisher: Elsevier Science Publishing Co Inc

Peptide and Peptidomimetic Therapeutics: From Bench to Beside is a comprehensive guide that provides applied, evidence-based instruction on the development and application of peptide therapeutics in disease treatment, drug discovery, and patient care. This resource is designed to empower researchers, clinicians, and students to harness the full potential of peptides and peptidomimetics and enhance the bioavailability, stability, efficiency, and selectivity of new therapeutics.

Over 20 esteemed experts in the field share their innovative approaches for identifying and advancing peptide and peptidomimetic therapeutics. The topics covered in this book span from fundamental peptide science to protein-protein interactions, peptide synthesis, and various modes of peptide drug delivery.

The first section delves into the basics of peptide science, covering topics such as peptide structure, synthesis, and characterization. It then explores protein-protein interactions, which are crucial in understanding the mechanisms of peptide-based therapeutics. The subsequent chapters focus on peptide synthesis, including methods such as solid-phase peptide synthesis, liquid-phase peptide synthesis, and genetic engineering.

Later chapters delve into the modes of peptide drug delivery, including cell penetration peptide and peptidomimetic delivery. These approaches aim to enhance the therapeutic efficacy of peptides by overcoming barriers such as cell membranes and targeting specific disease types. The book also explores the application of peptide therapeutics in infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders. Additionally, it discusses the use of antiparasitic and immunosuppressive peptidomimetics as potential therapeutics.

Throughout the book, real-world case studies and examples are provided to illustrate the practical applications of peptide and peptidomimetic therapeutics. These case studies showcase the successful translation of research findings from the laboratory to the clinic, highlighting the importance of interdisciplinary collaboration and patient-centered care.

Peptide and Peptidomimetic Therapeutics: From Bench to Beside is an essential resource for researchers, clinicians, and students interested in advancing the field of peptide therapeutics. It provides a comprehensive and up-to-date overview of the latest developments, techniques, and applications in this rapidly evolving area. By leveraging the power of peptides and peptidomimetics, this book offers the potential to revolutionize disease treatment and improve patient outcomes.

Dimension: 235 x 191 (mm)
ISBN-13: 9780128201411