Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity.  The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.  This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Format: Paperback / softback
Length: 438 pages
Publication date: 09 March 2023
Publisher: Springer Nature Switzerland AG

The recent advancements in the field of PK/PD methods and the development of nanoparticles for novel drug delivery systems have garnered significant attention. While there is a need for a consolidated published reference that comprehensively addresses these developments, this book fills the gap by providing a comprehensive exploration of the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of various drugs that are challenging to metabolize or achieve desired therapeutic effects with minimal toxicity.

The authors offer a comprehensive overview of biodistribution, with a particular emphasis on polymer and lipid nanoparticles. This thorough reference is structured into three parts: Modelling, Specific Carriers, and their Potential to Treat Specific Diseases.

In the first part, the authors delve into the theoretical foundations and modelling approaches employed in NPDDS. They discuss the use of computational simulations, in silico models, and experimental techniques to predict the pharmacokinetic behaviour of nanoparticles and their interactions with biological systems. This section provides a solid foundation for understanding the mechanisms underlying nanoparticle-drug interactions and enables the development of more accurate prediction models.

The second part focuses on specific carriers used in NPDDS, including polymers, lipids, and proteins. The authors explore the advantages and disadvantages of each carrier type, as well as their potential applications in drug delivery. They discuss the synthesis, characterization, and modification of these carriers to enhance their biocompatibility, stability, and drug loading capacity. This section provides valuable insights into the selection of appropriate carriers for specific drug targets and disease conditions.

The third part of the book explores the potential of NPDDS to treat specific diseases. The authors discuss the use of nanoparticles for targeted drug delivery, gene therapy, and imaging applications. They highlight the advantages of nanoparticles, such as their ability to enhance drug solubility, improve drug targeting, and reduce side effects. They also discuss the challenges and limitations associated with nanoparticle-based drug delivery, such as their stability in biological environments, immune response, and potential toxicity.

This comprehensive reference is an invaluable resource for researchers, pharmacists, and medical professionals involved in drug discovery, development, and delivery. It provides a detailed understanding of the recent progress in PK/PD methods and the development of nanoparticles for novel drug delivery systems. The authors' expertise and comprehensive coverage make this book an essential tool for anyone seeking to advance the field of nanoparticle-based drug delivery.

In conclusion, the recent advancements in PK/PD methods and the development of nanoparticles for novel drug delivery systems have opened up new avenues for improving drug efficacy and safety. This book provides a comprehensive exploration of the advantages of nanoparticle drug delivery systems and serves as a valuable resource for researchers, pharmacists, and medical professionals seeking to advance the field. By addressing the challenges and limitations associated with nanoparticle-based drug delivery, this reference contributes to the development of more effective and sustainable drug delivery systems for the treatment of various diseases.

Weight: 861g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030833978
Edition number: 1st ed. 2022