Pharmacological Advances in Central Nervous System Stimulants

Pharmacological Advances in Central Nervous System Stimulants, Volume 99, explores the therapeutic and abuse aspects of various stimulants, including long-standing and emerging ones, such as amphetamines, cocaine, and nicotine. The book covers topics such as transgenerational epigenetic inheritance, brain cholesterol homeostasis, and modeling methamphetamine use disorder. It also discusses second-generation stimulants, opioid co-use, age and sex differences in stimulant effects, modafinil, nicotine reward-related behaviors, and more.

Format: Hardback
Length: 312 pages
Publication date: 08 March 2024
Publisher: Elsevier Science Publishing Co Inc

Pharmacological Advances in Central Nervous System Stimulants,Volume 99 in the Mechanisms, Therapeutic Uses, and Abuse of Stimulants series, presents a comprehensive exploration of recent pharmacological advancements in the field of stimulants. This volume, spanning over 500 pages, showcases the investigation of stimulants' therapeutic applications, including their use in treating conditions such as ADHD, binge-eating, and narcolepsy. It also delves into the abuse aspects of various stimulants, some of which have been in use for decades, such as amphetamines, cocaine, and nicotine, while others are emerging, such as cathinones.

The book is organized into several chapters, each addressing different aspects of stimulant research. One notable chapter explores the transgenerational epigenetic inheritance of phenotypes associated with parental exposure to drugs of abuse. This chapter sheds light on the potential long-term effects of drug use on subsequent generations, emphasizing the importance of understanding these mechanisms for developing effective prevention and treatment strategies.

Another chapter focuses on the dysregulation of brain cholesterol homeostasis by psychostimulants. This chapter explores the impact of stimulants on brain lipid metabolism, which can have implications for cognitive function and addiction. The authors discuss the potential benefits and risks of using stimulants for treating conditions such as ADHD and obesity.

Modeling methamphetamine use disorder in mammals: sex differences in behavioral consequences and gene expression is another chapter that highlights the importance of studying stimulant addiction in different animal species. This chapter explores the sex-specific effects of methamphetamine use on behavior and gene expression, providing insights into potential gender-based differences in addiction vulnerability.

Additional sections in the book focus on second-generation stimulants, their pharmacological and clinical advances in treating ADHD and binge-eating disorder, the pharmacology of stimulant-opioid co-use, the role of age and sex in determining the risk for adverse consequences following exposure to amphetamines, modafinil, an atypical CNS stimulant, modulators of nicotine reward-related and reinforcement-related behaviors, methamphetamine effects on peripheral immune system, post-translational mechanisms in neurotransmitter efflux, the many enigmas of nicotine, genetic variation in the neuregulin-Erbb signaling pathway and substance use disorders, pharmacology and neurotoxicology of synthetic cathinones, and more.

Pharmacological Advances in Central Nervous System Stimulants,Volume 99 is a valuable resource for researchers, clinicians, and policymakers interested in understanding the therapeutic and abuse aspects of stimulants. The comprehensive coverage of topics and the inclusion of cutting-edge research make this book an essential addition to the field of neuroscience and addiction.

Weight: 450g
Dimension: 229 x 151 (mm)
ISBN-13: 9780443219337