Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary,Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades,and since the first article on P450 was published in 1962.

Format: Hardback
Length: 434 pages
Publication date: 12 August 2022
Publisher: Elsevier Science & Technology

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary,Volume 95, is a remarkable compilation of extensive contributions by researchers worldwide in the field of cytochrome P450 (P450) over the past six decades. Since the first article on P450 was published in 1962, the field has witnessed remarkable advancements. This latest release includes chapters on various captivating topics, such as Multiple conformations of cytochromes P450 and their relevance to predicting SAR (pharmacological response), Pharmacogenetics of the cytochromes P450 and their significance in drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and much more.

In addition to these insightful chapters, the book also features an additional section dedicated to Atypical kinetics of cytochrome P450 enzymes in drug metabolism. This section explores the unique mechanisms and factors that influence the metabolism of drugs by these enzymes. Furthermore, the book delves into Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, highlighting the importance of these enzymes in the production of therapeutic compounds. The use of engineered cytochrome P450s for accelerating drug discovery and development is explored, as well as the assessment of cytochrome P450 function using genetically engineered mouse models. The utilization of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter for anticipating drug Interactions is discussed.

This volume serves as a comprehensive repository of major progress to date in the field of P450. It also provides a platform for discussing possible future directions and inviting young researchers to join this exciting and important world of P450. The contributions by the authors and editors in this volume are invaluable, and they will undoubtedly inspire and guide future research endeavors in this field.

In conclusion, Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary,Volume 95 is a must-read for researchers, students, and professionals in the fields of pharmacology, toxicology, and medicine. It offers a comprehensive and up-to-date overview of the latest developments in the cytochrome P450 field, providing valuable insights into drug metabolism, drug discovery, and drug interactions.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323911092