Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides an overview of the latest research on using phytonutrients to treat neurological disorders, including isolation, characterization, and therapeutic applications, with a focus on mechanisms and safety profiles.

Format: Paperback / softback
Length: 416 pages
Publication date: 01 August 2022
Publisher: Elsevier Science Publishing Co Inc

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects is a comprehensive and up-to-date resource that delves into the latest research and developments surrounding the use of phytonutrients in the treatment of neurological disorders. This volume offers a thorough analysis of advancements in phytonutrient isolation, characterization, and therapeutic applications, with a particular focus on mechanisms and safety profiles. Additionally, it takes into account toxicological considerations, such as adverse drug reactions, toxicokinetics, and toxicodynamics. The book is organized into various sections, covering bioactive compound classes and biosynthesis pathways, general considerations including quality control, standardization, and technology, and toxicology.

Therapeutic Applications of Phytonutrients:

Phytonutrients have shown promising results in the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. These compounds have been found to possess anti-inflammatory, antioxidant, and neuroprotective properties, which can help mitigate the symptoms and progression of these disorders.

One of the key mechanisms by which phytonutrients exert their therapeutic effects is by modulating the activity of neurotransmitters. For example, some phytonutrients, such as flavonoids and terpenoids, have been shown to inhibit the activity of enzymes that break down neurotransmitters, such as acetylcholinesterase and beta-amyloid precursor protein. This can help increase the levels of neurotransmitters in the brain, which can improve cognitive function and reduce symptoms of neurological disorders.

Another therapeutic application of phytonutrients is in the treatment of neurodegenerative disorders. These disorders are characterized by the loss of neurons in specific regions of the brain, leading to cognitive decline and motor symptoms. Phytonutrients, such as anthocyanins and carotenoids, have been shown to protect neurons from damage and promote neurogenesis, which can help slow down the progression of these disorders.

Toxicological Considerations:

While phytonutrients have shown promising therapeutic effects, it is important to note that their use may also have toxicological considerations. Some phytonutrients, such as certain flavonoids and terpenoids, have been associated with adverse drug reactions, such as liver toxicity and gastrointestinal upset. Additionally, the long-term safety of phytonutrient supplementation is not fully understood, and more research is needed to determine the appropriate dosage and duration of treatment.

To address these toxicological concerns, researchers are exploring the use of phytonutrient extracts and formulations that are more standardized and well-characterized. Additionally, studies are being conducted to evaluate the safety of phytonutrient supplementation in different populations, including pregnant women, children, and individuals with pre-existing medical conditions.

Conclusion:

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides a comprehensive and insightful examination of the latest research and developments surrounding the use of phytonutrients in the treatment of neurological disorders. This volume highlights the therapeutic potential of phytonutrients and their ability to modulate neurotransmitter activity, protect neurons from damage, and promote neurogenesis. However, it is important to consider the toxicological considerations associated with their use and to explore the use of standardized and well-characterized formulations to ensure safety and efficacy. As research in this field continues to progress, phytonutrients may become an important tool in the treatment of neurological disorders and other chronic conditions.

Dimension: 235 x 191 (mm)
ISBN-13: 9780128244678