Precision Molecular Pathology of Glioblastoma

This book provides a comprehensive review of glioblastoma, covering histological review, molecular pathology, radiomics, neurosurgical focus, and treatment plans. It is intended for pathology residents, fellows, surgical pathologists, neuro-radiologists, oncologists, and radiation oncologists.

Format: Paperback / softback
Length: 266 pages
Publication date: 02 May 2022
Publisher: Springer Nature Switzerland AG

This comprehensive volume offers a balanced and realistic appraisal of the current landscape of glioblastoma, encompassing a wide range of topics. It begins with a thorough histological review, delving into traditional diagnostic techniques and the molecular pathology of glioma. Moving forward, the book explores modern radiomics, emphasizing its role in precision imaging and treatment planning. The neurosurgical focus is also emphasized, highlighting the critical role of surgical intervention in managing glioblastoma. Additionally, the text integrates treatment plans by neuro-oncologists, emphasizing the multidisciplinary approach required for optimal patient care.

The book delves into fundamental principles, such as epidemiology and etiology, and provides an updated 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors. Chapters cover a broad overview of common molecular techniques employed in molecular pathology, with a special emphasis on their application in developing countries. Key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatments are explored in depth, shedding light on the complex mechanisms at play in glioblastoma. Immunohistochemical surrogates for critical molecular pathology markers are also discussed, offering valuable insights into diagnosis and treatment.

The volume concludes with comprehensive reviews on radiomics, animal and stem cell models of glioblastoma, and the emerging field of Glioblastoma Neuroscience. Radiomics utilizes advanced imaging techniques to quantify tumor characteristics, providing valuable insights into tumor behavior and response to therapy. Animal and stem cell models offer valuable tools for studying glioblastoma biology and testing novel therapies in a controlled environment. The chapter on Glioblastoma Neuroscience explores the intersection of neuroscience and pathology, highlighting the importance of understanding the neurobiological mechanisms underlying glioblastoma development and progression.

Precision Molecular Pathology of Glioblastoma is designed to cater to a diverse audience. It serves as a valuable resource for pathology residents and fellows seeking to gain expertise in glioblastoma, providing a comprehensive overview of the disease's pathology, diagnosis, and management. General surgical pathologists who need to familiarize themselves with modern glioblastoma classification will also find this book invaluable. Additionally, neuro-radiologists, oncologists, and radiation oncologists seeking a holistic perspective on glioblastoma diagnosis and management will find this text particularly useful.

In summary, this comprehensive volume offers a thorough and up-to-date exploration of glioblastoma, encompassing histological review, molecular pathology, radiomics, neurosurgical focus, and multidisciplinary treatment approaches. It serves as a valuable resource for pathology professionals, researchers, and healthcare practitioners alike, contributing to improved understanding and treatment of this challenging disease.

Weight: 438g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030691721
Edition number: 1st ed. 2021