Protein Kinase-mediated Decisions Between Life and Death

Protein phosphorylation via protein kinases is an essential process that alters cellular functions and is involved in various human diseases. Recent developments in quantitative proteomics provide insights into kinase inhibitor selectivity and modes of action. This book discusses the latest opinions on "Protein Kinases" related pathways that threaten human health and life, and the chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License.

Format: Paperback / softback
Length: 415 pages
Publication date: 05 February 2022
Publisher: Springer Nature Switzerland AG

Protein phosphorylation via protein kinases is a fundamental process that profoundly impacts the physiological and pathological functions of cells. These enzymes play a crucial role in regulating critical aspects of cell life and death decisions, making them essential players in cellular homeostasis. Protein kinases are frequently implicated in a wide range of human diseases, including aging, cellular senescence, immune system and endothelial dysfunctions, cancer, insulin resistance, cholestasis, and neurodegenerative diseases. Moreover, their involvement in bacterial resistance in persistent infections further highlights their significance in health and disease.

Recent advancements in quantitative proteomics have shed light on the intricacies of kinase inhibitor selectivity and their modes of action within the biological context. This field has provided valuable insights into the mechanisms by which protein kinases regulate cellular processes and their potential as therapeutic targets.

The book "Protein Kinase-mediated Decisions Between Life and Death" aims to provide a comprehensive and up-to-date perspective on protein kinases and their role in human health. It is designed to appeal to a broad audience, including clinicians, basic science researchers, and students. Chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License via the link: link.springer.com.

By delving into the latest research and clinical developments, this book aims to equip readers with the knowledge and tools necessary to understand the complexities of protein kinase-mediated signaling pathways and their implications for human health. It serves as a valuable resource for researchers, healthcare professionals, and students interested in exploring the role of protein kinases in disease and developing new therapeutic strategies to combat these disorders.

Weight: 810g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030498467
Edition number: 1st ed. 2021