Proteostasis and Proteolysis

Proteostasis controls protein biogenesis, trafficking, folding, and degradation, and this book focuses on two protein breakdown/degradation processes: the ubiquitin-proteasome system and autophagy. Chapter 2 is available for free download.

Format: Hardback
Length: 251 pages
Publication date: 23 November 2021
Publisher: Taylor & Francis Ltd

Proteostasis is a vital biological mechanism that orchestrates the intricate processes of protein biogenesis, trafficking, folding, and degradation. It encompasses a network of biological pathways that work in harmony to maintain the stability and functionality of proteins within cells. This comprehensive book delves into two crucial protein breakdown/degradation processes: proteolysis, which plays a vital role in a well-functioning proteostatic system.

The ubiquitin-proteasome system and autophagy are two prominent components of this system. Proteolysis refers to the breakdown of proteins into smaller fragments by enzymes known as proteases. It plays a crucial role in various cellular processes, including tissue remodeling, immune response, and the regulation of protein levels. The ubiquitin-proteasome system is a highly efficient and regulated pathway that involves the attachment of ubiquitin molecules to target proteins, followed by their degradation by proteasomes. This process ensures the timely removal of damaged or misfolded proteins, maintaining cellular homeostasis.

Autophagy, on the other hand, is a self-degrading process in which cells recycle their own components, including damaged or obsolete proteins. It involves the formation of cytoplasmic vesicles called autophagosomes, which engulf and degrade cellular contents. Autophagy serves as a protective mechanism against cellular stress, such as nutrient deprivation or protein aggregation, and plays a role in cell survival and longevity.

Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license. This chapter provides an in-depth exploration of the ubiquitin-proteasome system and autophagy, shedding light on their mechanisms, regulation, and clinical implications. By understanding these protein breakdown/degradation processes, researchers and healthcare professionals can gain a deeper insight into the underlying mechanisms of various diseases and develop innovative therapies to address protein-related disorders.

In conclusion, proteostasis is a fundamental biological process that ensures the stability and functionality of proteins within cells. Proteolysis, specifically the ubiquitin-proteasome system and autophagy, are two crucial protein breakdown/degradation processes that play essential roles in maintaining cellular homeostasis and responding to cellular stress. This book offers valuable insights into these processes, making it a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the complex world of protein biology.

Weight: 754g
Dimension: 183 x 262 x 20 (mm)
ISBN-13: 9780367499327