Quorum Quenching: A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development

Antibiotic resistance is a global health concern, and inhibiting quorum sensing is a promising route to new pharmaceuticals and controlling biofilm formation and growth. This book covers the biology of quorum sensing and quenching, potential sources of QQ enzymes and other inhibitors, and potential biotech applications. It is an ideal companion to researchers in chemical biology and medicinal chemistry.

Format: Hardback
Length: 400 pages
Publication date: 15 December 2023
Publisher: Royal Society of Chemistry

Antibiotic resistance is a major global health concern, with strains of pathogenic microorganisms such as MRSA becoming increasingly difficult to treat. Alternative methods for tackling these microorganisms are in high demand. One potential target for new therapeutics is inhibition of quorum sensing, which is the process by which microorganisms communicate and form biofilms in a density-dependent manner. Quorum quenching (QQ) is a promising approach to controlling biofilm formation and growth. This book provides a comprehensive overview of quorum sensing and quenching, covering the biology, mechanism, and potential biotech applications of QQ enzymes and other inhibitors. It also explores the potential for new drug development from QQ, covering topics such as protein engineering, imaging, computational studies, and integrated systems. The book is an ideal companion for researchers in chemical biology, medicinal chemistry, biofilm formation, quorum sensing, antimicrobial development, synthetic biology, and enzymology.

Weight: 801g
Dimension: 234 x 156 x 25 (mm)
ISBN-13: 9781839167614