Rational Drug Design: Methods and Protocols

This volume covers various aspects of rational drug design, including synthesis, methodologies, computational methods, and ADMET properties. It is written in the Methods in Molecular Biology series format and includes step-by-step protocols, troubleshooting tips, and lists of necessary materials.

Format: Hardback
Length: 465 pages
Publication date: 24 July 2018
Publisher: Humana Press Inc.

This comprehensive volume delves into diverse aspects of rational drug design, encompassing the synthesis of novel bioactive drugs, the development and application of innovative methodologies, computational approaches invaluable for establishing novel drug discovery strategies, and the evaluation of physical-chemical and ADMET properties of designed potential drugs. Organized into chapters, the book guides readers through various topics, including amyloid deposits, Saturation Transfer Difference (STD) NMR methods, bioguided design approaches, the significance of lipophilicity in drug design, ADMET analysis, FRET techniques, structural biology, and homology modeling. Written in the renowned Methods in Molecular Biology series format, each chapter features an introduction to its respective topic, a comprehensive list of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and valuable tips on troubleshooting and avoiding common pitfalls. Authored by esteemed experts in the field, Rational Drug Design: Methods and Protocols strives to provide authoritative and cutting-edge guidance, ensuring successful outcomes in the ongoing exploration of this crucial domain.

Weight: 1072g
Dimension: 183 x 260 x 36 (mm)
ISBN-13: 9781493986293
Edition number: 1st ed. 2018