Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

Overexpression of receptor tyrosine kinases (RTKs) is linked to cancer and neurodegenerative and psychiatric disorders. This book discusses the structure, activation, functions, gene regulation, and signaling pathways of RTKs in these disorders, as well as the potential repositioning of anti-cancer RTK inhibitors and other protein kinase inhibitors for therapeutic use.

Format: Paperback / softback
Length: 604 pages
Publication date: 08 June 2023
Publisher: Elsevier Science Publishing Co Inc

Overexpression of receptor tyrosine kinases (RTKs) has been linked to cancer, with mounting evidence indicating that dysregulation of these enzymes is observed in numerous neurodegenerative and psychiatric disorders. This comprehensive resource, Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders, offers a foundational understanding of RTKs structure, activation, functions, mechanisms of action, gene regulation, and signaling pathways in the developing central nervous system (CNS), adult normal CNS, neurodegenerative, and psychiatric disorders. Furthermore, it delves into the structure, function, activation, and therapeutic potential of various growth factors.

Drawing upon the expertise of international experts in the field, this book provides a comprehensive exploration of the results of pre-clinical and clinical studies of repositioning anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in diverse neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Additionally, it addresses the challenges and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.

The book is organized into five chapters, each dedicated to a specific aspect of RTKs and their role in neurodegenerative and psychiatric disorders. Chapter 1 provides an introduction to RTKs and their significance in cancer and neurodegenerative diseases. Chapter 2 explores the structure, activation, and functions of RTKs in the CNS. Chapter 3 discusses the mechanisms of action and gene regulation of RTKs in neurodegenerative disorders. Chapter 4 highlights the role of RTKs in psychiatric disorders, including anxiety, depression, alcohol use disorder, and schizophrenia. Chapter 5 explores the therapeutic potential of repositioning RTKIs and other protein kinase inhibitors in neurodegenerative and psychiatric disorders.

Throughout the book, international experts in the field offer insightful discussions and provide up-to-date information on the latest research findings. The book is extensively referenced, with a comprehensive list of references and further reading materials for those seeking to delve deeper into the subject matter.

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders is a valuable resource for researchers, clinicians, and students interested in understanding the role of RTKs in neurodegenerative and psychiatric disorders. It serves as a comprehensive guide that covers the structural and functional aspects of RTKs, their mechanisms of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative, and psychiatric disorders. Additionally, it explores the therapeutic potential of repositioning RTKIs and other protein kinase inhibitors in these disorders, providing a valuable reference for those working in the field.

Weight: 1254g
Dimension: 199 x 242 x 34 (mm)
ISBN-13: 9780443186776