Ruthenium Chemistry

This book discusses Ruthenium complexes as chemotherapeutic agents, particularly for tumor site treatment. Nanoparticles are emerging as an effective alternative, but synthesizing a drug of nanoparticle size that uses the blood transport mechanism to reach the tumor site is more appropriate. Ruthenium complexes are of interest due to their less toxicity and effective bio-distribution. The book will cover synthesis, characterization, and applications of various Ruthenium complexes, including their introduction to chemotherapy, classification, shape and binding-selectivity, DNA binding, cleavage studies, and cytotoxicity. It will be beneficial to researchers, scientists, and biomedical professionals, and will empower the younger generation to create new opportunities in ruthenium chemistry and medicine.

Format: Hardback
Length: 386 pages
Publication date: 19 March 2018
Publisher: Pan Stanford Publishing Pte Ltd

This comprehensive book delves into the realm of Ruthenium complexes as chemotherapeutic agents, focusing specifically on their application at tumor sites. It has emerged as one of the most challenging tasks in cancer therapy, and nanoparticles have emerged as a promising alternative to traditional chemotherapeutic approaches. Nanoparticles have demonstrated their usefulness in this context. However, considering the complexities of organ systems, it is more appropriate to synthesize a drug of nanoparticle size that utilizes the blood transport mechanism to reach the tumor site and effectively regress cancer. Ruthenium (Ru) complexes, due to their reduced toxicity and efficient bio-distribution, have gained significant interest in recent years. Moreover, luminous Ru-complexes can be synthesized in nanoparticle size, allowing for direct tracing at the tissue level.

The book will encompass a wide range of topics, including the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. It will provide an introduction to chemotherapy, covering the classification of Ru- complexes based on their oxidation states and geometry. The book will also delve into Ruthenium complexes of nano size, exploring their shape and binding selectivity, as well as their interactions with DNA. It will discuss DNA cleavage studies and cytotoxicity, providing valuable insights into the potential therapeutic benefits of Ruthenium complexes.

This book is designed to be of immense benefit to researchers, scientists, and biomedical professionals. It will empower the younger generation to explore the vast potential of Ruthenium chemistry in material science and medicine. Furthermore, it will serve as a valuable resource for national and international research laboratories, as well as academia, with an interest in the area of coordination chemistry, particularly Ruthenium compounds, and their applications.

In conclusion, this book offers a comprehensive and in-depth exploration of Ruthenium complexes as chemotherapeutic agents, highlighting their potential for cancer therapy and their applications in nanoparticle-based drug delivery. It is a valuable resource for researchers, scientists, and professionals in the field, and will contribute to the advancement of coordination chemistry and its applications in medicine.

Weight: 796g
Dimension: 163 x 236 x 30 (mm)
ISBN-13: 9789814774390