Shulph Ink
Spatial Genome Organization: Methods and Protocols
Spatial Genome Organization: Methods and Protocols
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- More about Spatial Genome Organization: Methods and Protocols
This detailed volume explores a variety of cutting-edge techniques used to interrogate spatial genome organization, including chromosome conformation capture (3C), targeted Hi-C approaches, sequencing-based approaches to assess nuclear environment, single-cell technologies, and methods for acute manipulations of chromatin architecture. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Format: Hardback
Length: 333 pages
Publication date: 23 July 2022
Publisher: Springer-Verlag New York Inc.
This extensive volume delves into a diverse array of cutting-edge techniques employed to investigate spatial genome organization. The book commences with a comprehensive section covering the pivotal chromosome conformation capture (3C) technique, which serves as a foundational approach. Subsequently, the collection proceeds with chapters dedicated to targeted Hi-C approaches, sequencing-based methods to evaluate nuclear environment, and single-cell technologies to enhance our understanding of the heterogeneity and dynamics of nuclear architectures. To facilitate the interrogation of functional aspects of spatial chromatin organization in genomic control, the final section presents methodologies for acute manipulations of chromatin architecture. Authored for the renowned Methods in Molecular Biology series, the chapters encompass introductions to their respective topics, comprehensive lists of the necessary materials and reagents, detailed step-by-step laboratory protocols that are readily reproducible, and valuable tips on troubleshooting and avoiding known pitfalls. Spatial Genome Organization: Methods and Protocols stands as an invaluable resource for researchers seeking the most effective techniques to address their unique research inquiries.
Weight: 852g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071624968
Edition number: 1st ed. 2022
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