Spray Drying of Vaccines: From Laboratory Research to Industrial Applications

This book discusses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. It aims to familiarize readers with the advances in vaccine spray drying technology and its potential applications in the production of dry powder vaccines. The book covers topics such as design of aseptic spray dryers, parameters affecting the process, sterile powder processing, cleaning procedures, and powder filling. It also compares different drying technologies for the production of dry powder vaccines and highlights research studies published over the past 30 years. Potential applications of spray-dried vaccines and routes of administration are presented, and an outlook is given on the commercialization of aseptic spray-dried vaccines. The book is targeted at academics, researchers, vaccine developers, industry experts, students, and funders in the vaccine formulation and biopharmaceutical processing industry.

Format: Hardback
Length: 589 pages
Publication date: 04 April 2023
Publisher: Springer International Publishing AG

This comprehensive book delves into the stabilization of vaccine powders through spray drying, offering a comprehensive overview of the current state-of-the-art on both a laboratory and industrial scale. Its primary objective is to familiarize readers with the latest advancements in vaccine spray drying technology, enabling them to better understand its potential applications. The book specifically focuses on various aspects, including the design of aseptic spray dryers, the parameters that influence the spray drying process, the sterile processing of powders, cleaning procedures, and powder filling. Moreover, it compares different drying technologies used in the production of dry powder vaccines, highlighting the unique capabilities of spray drying as a particle technology for vaccines.

Special attention is given to comprehensive research studies on spray-dried vaccines published over the past three decades, encompassing laboratory research and clinical trials. Key findings from these studies are presented, providing valuable insights into the effectiveness and safety of spray-dried vaccines. Potential applications of spray-dried vaccines and the various routes of administration are explored in detail, offering a comprehensive understanding of their potential benefits in the field of immunization.

Finally, the book provides an outlook on the current status of aseptic spray-drying of vaccines and the challenges that need to be overcome for commercial success. It aims to serve as a valuable resource for academics, researchers, vaccine developers, industry experts, students, and potentially funders, including government agencies, involved in the field of vaccine formulation and biopharmaceutical processing. Additionally, the book serves as a comprehensive reference source for those engaged in the vaccine industry.

Weight: 1198g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031243226
Edition number: 1st ed. 2023