The Chemical Biology of Thrombin

Thrombin, a regulatory protease, has been extensively studied due to its availability in highly purified form. This book covers the discovery of thrombin by Andrew Buchanan in 1842 to the present, with a focus on research conducted by the author and his colleagues. It discusses the purification of thrombin, the role of exosites in thrombin function, and the development of an oral inhibitor for thrombosis.

Format: Hardback
Length: 268 pages
Publication date: 02 May 2022
Publisher: Taylor & Francis Ltd

This book is a thorough examination of thrombin, particularly in its role as a regulatory protease. The availability of highly purified thrombin has facilitated rapid advancements in our understanding of this crucial macromolecule in cell biology. The text primarily concentrates on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present day. The author and his colleagues have conducted substantial research in this field. The author's pioneering work on thrombin purification laid the foundation for much subsequent research on the molecule. This volume serves as a framework for future studies, made possible by the discovery of the significance of exosites in thrombin function.

The current work presents the development of an oral inhibitor of thrombin for the prevention of thrombosis.

Key Features:

Reviews the history of Thrombin (Fibrin Ferment)

Documents the relation of protein engineering and chemical modification in the study of thrombin

Summarizes the interaction of thrombin with fibrinogen and fibrin

Outlines the role of exosites in thrombin function

Describes the development of an oral inhibitor for thrombin

Weight: 570g
Dimension: 162 x 241 x 24 (mm)
ISBN-13: 9781138055902