The Extracellular Matrix and the Tumor Microenvironment

This book provides an overview of the important and best-studied extracellular and pericellular molecules of the tumor microenvironment, their role in tumor development, and cancer progression. It covers the biochemical and biophysical background of ECM changes, the cooperative activity of the ECM in tumor metabolism, and its critical role in tumor angiogenesis. It also discusses the potential of the ECM as biomarkers, therapeutic targets, and mechanisms of resistance-associated changes. The book is intended for early career scientists, advanced researchers, and clinicians interested in understanding the role of the ECM in cancer biology.

Format: Hardback
Length: 494 pages
Publication date: 07 July 2022
Publisher: Springer Nature Switzerland AG

This comprehensive book delves into the intricate world of extracellular and pericellular molecules within the tumor microenvironment, shedding light on their crucial roles in tumor development and cancer progression. Spanning twelve chapters, it provides a thorough exploration of the biochemical and biophysical background of the altered extracellular matrix (ECM) in cancerous tissues, comparing it to its physiological state. The reader gains insights into the major deregulated ECM components and their associations with various cancer-related outcomes, including survival, inflammation, and metastasis. Furthermore, the book highlights recent data revealing the cooperative activity of the ECM in promoting tumor metabolism and advancing cancer progression.

Two dedicated chapters focus specifically on the pivotal role of the ECM in tumor angiogenesis, elucidating its connection to cellular infiltration and the metastatic behavior of tumors. The final section delves into how the ECM influences the effectiveness of immuno- and chemotherapy in cancer patients, exploring its potential as biomarkers for diagnosis, prognosis, and therapeutic targets. Additionally, it unravels the mechanisms behind resistance-associated changes in the ECM, offering valuable insights into the complex interplay between the ECM and cancer therapy.

This book is a captivating read for anyone seeking to deepen their understanding of the ECM and cancer biology. It serves as an excellent introduction for early career scientists, providing a valuable tool for studying this complex field. Advanced researchers and clinicians will find it a valuable resource, as it offers a broader perspective on the role of the ECM in influencing every cancer hallmark and the response to cancer treatments. The work serves as a catalyst for future research and underscores the importance of considering the ECM as a critical factor in the development of cancer therapeutics.

The Biology of Extracellular Matrix series is published in collaboration with renowned publishers, ensuring the dissemination of cutting-edge research to a global audience.

Weight: 916g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030997076
Edition number: 1st ed. 2022