The Guinea Pig Model: An Alternative Method for Vaccine Potency Testing

This book provides a comprehensive summary of the development and statistical validation of a guinea pig model for potency testing of viral antigens in combined vaccines used in cattle to control respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows for the simultaneous testing of vaccine quality for all viral antigens in aqueous and oil-adjuvanted formulations, and the methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus is recommended as guidelines for 30 countries in the CAMEVET forum, including the US.

Format: Hardback
Length: 152 pages
Publication date: 10 April 2023
Publisher: Taylor & Francis Ltd

This comprehensive book delves into the development and rigorous statistical validation of a guinea pig model as an innovative alternative for potency testing of viral antigens included in combined vaccines used in cattle to combat the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model's remarkable capability allows for the simultaneous evaluation of vaccine quality for all the viral antigens present in both aqueous and oil-adjuvanted formulations of bovine vaccines, using a single serum sample.

Recognized by the esteemed CAMEVET (Committee for the Administration of Veterinary Medicinal Products) as guidelines for 30 countries, including the United States, the methodology proposed for controlling bovine herpes virus, parainfluenza, and rotavirus has proven invaluable in the fight against these detrimental pathogens.

The book offers a wealth of information, covering key features such as:

• A comprehensive review of combined vaccines used for cattle.
• Summarization of animal models employed for vaccine testing.
• Focal attention on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus.
• Providing valuable guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity.

By undertaking extensive research and rigorous validation, this book emerges as a valuable resource for researchers, veterinarians, and industry professionals seeking to enhance the safety and efficacy of combined vaccines in cattle. Its insights contribute to the ongoing efforts to combat livestock diseases and ensure the well-being of animals worldwide.

Weight: 470g
ISBN-13: 9781032446400