Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans

This book uses C. elegans as a model animal to study the toxicity of toxicants at environmentally relevant concentrations, introducing molecular signaling pathways and networks for intestinal, neuronal, and germline regulation.

Format: Paperback / softback
Length: 360 pages
Publication date: 22 January 2023
Publisher: Springer Verlag, Singapore

This comprehensive book employs the nematode Caenorhabditis elegans as a model organism to delve into the intricate mechanisms of toxicant-induced toxicity at environmentally relevant concentrations. It explores the systematic integration of diverse molecular signaling pathways, including G protein-coupled receptors and ion channels, in regulating the toxicity of toxicants at these environmentally significant levels. Furthermore, the book delves into the intricate molecular networks encompassing the intestinal, neuronal, and germline compartments, which are essential for the regulation of toxicant toxicity at environmentally relevant concentrations. The primary objective of this book is to offer a systematic and comprehensive understanding of the knowledge system pertaining to toxicology at environmentally relevant concentrations within the context of C. elegans.

Through detailed explanations and illustrative examples, the book elucidates the mechanisms by which toxicants exert their harmful effects on the organism. It discusses the various cellular and molecular processes involved in toxicant recognition, uptake, metabolism, and detoxification. The book also sheds light on the role of genetic variations and environmental factors in modulating toxicant susceptibility and toxicity.

Moreover, the book explores the application of C. elegans as a powerful tool for toxicology research. It discusses the advantages of using this model organism, such as its small size, rapid reproduction, and well-defined genetic background. It highlights the use of C. elegans in identifying novel toxicants, understanding the mechanisms of toxicity, and developing novel therapeutics.

In conclusion, this book serves as a valuable resource for researchers, students, and professionals interested in toxicology, environmental science, and genetics. It provides a comprehensive and up-to-date understanding of the mechanisms of toxicant-induced toxicity at environmentally relevant concentrations and offers insights into the potential applications of C. elegans in toxicology research.

Weight: 575g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811667480
Edition number: 1st ed. 2022