Translational Biotechnology: A Journey from Laboratory to Clinics

Translational Biotechnology: A Journey from Laboratory to Clinics provides an interdisciplinary approach to biotechnology, covering topics from basic concepts to novel methodologies and discussing biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology.

\n Format: Paperback / softback
\n Length: 452 pages
\n Publication date: 21 January 2021
\n Publisher: Elsevier Science Publishing Co Inc
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Translational Biotechnology: A Journey from Laboratory to Clinics is a comprehensive and interdisciplinary guide to biotechnology, aimed at bridging the gaps between fundamental and applied research. This book offers cutting-edge insights into translational biotechnology by covering a wide range of topics, from basic concepts to innovative methodologies. It delves into various aspects of biotechnology, including biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, system and synthetic biology. Furthermore, it explores drug discovery, precision medicine, and the socioeconomic impact of translational biotechnology. This book is an invaluable resource for bioinformaticians, biotechnologists, and professionals in the biomedical field who seek to gain a deeper understanding of this rapidly evolving field.

The book begins by providing an overview of the field, including its historical development, current trends, and potential applications. It then delves into specific topics, such as biotechnology-based therapeutics, which encompass the development of drugs and vaccines using biological technologies. The authors discuss the various stages of drug discovery, from target identification to preclinical testing and clinical trials. They also explore the use of genetic engineering and other advanced technologies to modify biological molecules and enhance their therapeutic properties.

Pathway and target discovery is another crucial aspect of translational biotechnology. The authors discuss the methods used to identify and characterize biological pathways and their associated targets, which are essential for developing targeted therapies. They explore the use of high-throughput screening techniques, such as genomics and proteomics, to identify novel drug candidates and biomarkers. Additionally, they discuss the importance of understanding the molecular mechanisms underlying diseases to develop more effective treatments.

Biological therapeutic modalities are another area of focus in the book. The authors discuss the use of biological agents, such as proteins, antibodies, and stem cells, in the treatment of diseases. They explore the advantages and challenges of these agents, including their safety and efficacy, as well as their potential side effects. They also discuss the development of personalized medicine approaches, which tailor treatments to individual patients based on their genetic makeup and disease characteristics.

Translational bioinformatics is a critical component of translational biotechnology. The authors discuss the methods used to analyze and interpret large datasets, such as genomics and proteomics, to identify patterns and relationships between biological molecules and diseases. They explore the use of bioinformatics tools and algorithms to predict the effects of genetic mutations and identify potential drug targets. Additionally, they discuss the importance of integrating data from different sources and platforms to gain a comprehensive understanding of biological processes.

System and synthetic biology are emerging fields that are revolutionizing the field of biotechnology. The authors discuss the use of engineered systems, such as bacteria and yeast, to produce biological compounds and materials. They explore the advantages and challenges of these systems, including their scalability and cost-effectiveness, as well as their potential applications in drug discovery and other fields. Additionally, they discuss the use of synthetic biology techniques, such as DNA sequencing and gene editing, to create new biological entities and modify existing ones.

Drug discovery is another critical aspect of translational biotechnology. The authors discuss the methods used to identify and develop new drugs, including small molecule drugs, biologics, and gene therapies. They explore the drug development process, from preclinical testing to clinical trials and regulatory approval. They also discuss the challenges and risks associated with drug discovery, including the high cost of development and the long approval process.

Precision medicine is a promising approach to healthcare that aims to tailor treatments to individual patients based on their genetic makeup and disease characteristics. The authors discuss the principles of precision medicine and the methods used to identify and develop personalized treatments. They explore the use of genetic testing, biomarkers, and other advanced technologies to diagnose and treat diseases. Additionally, they discuss the ethical and social implications of precision medicine, including the potential for discrimination and the need for equitable access to healthcare.

The socioeconomic impact of translational biotechnology is another important topic covered in the book. The authors discuss the economic benefits of biotechnology, including job creation, innovation, and economic growth. They also discuss the challenges and risks associated with biotechnology, such as intellectual property disputes, safety concerns, and the potential for unintended consequences. Additionally, they discuss the role of government policies and regulations in promoting the responsible and ethical use of biotechnology.

In conclusion, Translational Biotechnology: A Journey from Laboratory to Clinics is a comprehensive and interdisciplinary guide to biotechnology that offers valuable insights into the field's latest developments and applications. The book is written in a clear and accessible style, making it suitable for students, researchers, and professionals in the biomedical field. By covering a wide range of topics, from basic concepts to innovative methodologies, this book provides a solid foundation for understanding and advancing translational biotechnology. Whether you are interested in drug discovery, precision medicine, or the socioeconomic impact of biotechnology, this book is an essential resource for anyone seeking to stay up-to-date with the latest advancements in this exciting field.

\n Weight: 908g\n
Dimension: 192 x 236 x 35 (mm)\n
ISBN-13: 9780128219720\n \n