Vasoplegic Endothelial Dysfunction: Circulatory Shock and Methylene Blue

Cardiocirculatory shock is a significant organ failure condition, and Methylene Blue (MB) is a lifesaving agent. This book discusses MB's conceptual aspects, physiology, and application in the care of critically ill patients. It is organized in four parts, covering endothelial dysfunction, MB, acid-base balance, and therapeutic use of inhaled nitric oxide. The combination of three recently proposed concepts, wide-spectrum vasopressors, vasopressor economy strategies, and microcirculation protection, may help improve outcomes in critically ill patients.

Format: Paperback / softback
Length: 144 pages
Publication date: 02 June 2022
Publisher: Springer Nature Switzerland AG

Cardiocirculatory shock is a severe and potentially life-threatening organ failure condition that requires immediate medical attention. Methylene blue (MB) has been recognized as a valuable tool in the treatment of cardiocirculatory shock, but its lifesaving potential is often underestimated. In this comprehensive work, experienced authors delve into the key concepts of MB, highlighting essential experimental data while emphasizing its application in the care of critically ill patients.

The book is organized into 18 chapters, neatly structured in four parts. The first part provides an introduction to the general conceptual aspects and physiology of the endothelium, the thin layer of cells that line the blood vessels. The second part focuses on the particularities of endothelial dysfunction in different types of shock, including cardiogenic, septic, and neurogenic shock. Methylene blue is discussed in depth in the third part, exploring its mechanisms of action, dosage, and potential side effects.

In the fourth part, the authors describe specific situations where endothelial dysfunction occurs, such as during heart surgery and organ transplantation. They also touch upon the complementary subjects of acid-base balance and the therapeutic use of inhaled nitric oxide. Finally, the book explores potential therapeutic alternatives for vasoplegic endothelial dysfunction, with MB emerging as a promising adjuvant to sympathomimetic amines.

The authors propose a combination of three recently proposed concepts that may enhance the effectiveness of MB in treating cardiocirculatory shock. These concepts include the use of wide-spectrum vasopressors, vasopressor economy strategies, and microcirculation protection against the harmful effects of using high concentrations of amines. By implementing these strategies, healthcare professionals can improve the outcomes for critically ill patients with cardiocirculatory shock.

This book's translational approach makes it accessible to a wide range of readers within the health specialties of medicine, biomedicine, physiotherapy, nursing,odontology, and basic science. Its comprehensive coverage of cardiocirculatory shock and the role of MB provides valuable insights for healthcare professionals seeking to improve the care of their patients. Whether you are a medical practitioner, researcher, or student, this book is a must-read for anyone interested in advancing the understanding and treatment of cardiocirculatory shock.

Weight: 267g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030740986
Edition number: 1st ed. 2021